Rare Papillary Breast Carcinoma Incidentally Discovered After Trauma-Induced Hematoma.

Papillary carcinoma of the breast is rare, comprising only 0.5% incidence of all breast cancers. Clinically the disease presents in postmenopausal women as a painless breast lump with possible bloody nipple discharge. Prognosis is favorable due to its slow growth. We present a 61-year-old woman incidentally diagnosed with papillary breast carcinoma after presenting with a trauma-induced hematoma of the right breast. The patient presented to our surgery oncology clinic for persistent right breast swelling secondary to a fall, despite initial incision and drainage (I&D) six weeks prior. She had no history of breast cancer. On presentation, her right breast was distended demonstrating an approximately 20cm ill-defined solid mass with skin changes consistent with a tense hematoma. CT scan demonstrated a large complex cystic and solid breast mass measuring 15.2cmx11.8cmx15.2cm with irregular peripheral solid hyperdense polypoid components. She then underwent a right breast incisional biopsy and hematoma evacuation. Frozen sections of the mass outer cavity wall and papillary projections were consistent with encapsulated papillary carcinoma (EPC). The patient was lost to follow-up and did not obtain definitive treatment. Breast cancer rarely presents as a breast hematoma. However, as in this case, if the hematoma fails to resolve, further investigation is warranted. The prognosis of EPC is excellent when identified and treated appropriately.

Shared Book-Reading in Early Childhood Education: Teachers' Mediation in Children's Communicative Development.

Fostering communicative skills in young children is essential for their holistic development. Book-reading activities have been shown to be a valuable tool for supporting communicative exchanges between children and adults, but there is limited research on actual educational practices with children under 3 years old. This experimental study explores teaching practices in Chilean early childhood education with children from 4 to 17 months of age. We focused on children's performance of diverse communicative signs, as well as on the effect of the teacher's mediation (signs and strategies) in a triadic shared-reading interaction (teacher-child-book). The study is part of a larger cross-sectional project. We conducted an experimental study following a pre-test-post-test design with 11 children, who were randomly assigned to either the control or the experimental group. In addition, we conducted a 6-week intervention on shared book reading between the pre- and post-test stages. We observed that children used a wide range of communicative signs when engaging in shared interactions with their teacher and different books. In the experimental group, children performed more communicative signs after participating in the intervention than at the beginning of the study. The reading experience that they gained through the intervention could also explain the larger proportion of uses of the books, as compared to their control counterparts. Additionally, children performed different combinations of vocalizations, words, or repetitions within a single use. The conventional use of a book is not evident for an infant, and as such it requires the systematic and semiotically mediated action of an adult to be consolidated. We conclude that offering preschool teachers a diverse selection of books enables them to better adjust to the particularities of each child. In this scenario educators are able to promote efficient spaces for children's participation, increasing the complexity and variety of their communicative repertoire.

In vitro antitumor, pro-inflammatory, and pro-coagulant activities of Megalopyge opercularis J.E. Smith hemolymph and spine venom.

Contact with stinging spines venom from several Lepidoptera larvae may result in skin lesions. In Mexico, envenomation outbreaks caused by Megalopyge opercularis were reported between 2015 and 2016. The aim of this study was to identify the venomous caterpillars in Nuevo Leon, Mexico and evaluate several biological activities of their hemolymph (HEV) and spine setae (SSV) venoms. M. opercularis was identified by cytochrome oxidase subunit (COI) designed primers. HEV and SSV extracts cytotoxic activity was assessed on the L5178Y-R lymphoma cell line. For apoptotic cells number and apoptosis, cells were stained with acridine orange/ethidium bromide and validated by DNA fragmentation. Human peripheral blood mononuclear cells (hPBMC) cytokine response to the extracts was measured by the cytometric bead array assay. Extracts effect on pro-coagulation activity on human plasma was also evaluated. HEV and SSV extracts significantly inhibited (p < 0.01) up to 63% L5178Y-R tumor cell growth at 125-500 µg/mL, as compared with 43% of Vincristine. About 79% extracts-treated tumor cells death was caused by apoptosis. Extracts stimulated (p < 0.01) up to 60% proliferation of resident murine lymphocytes, upregulated IL-1ß, IL-6, IL-8, and TNF-α production by hPBMC, and showed potent pro-coagulant effects. The pharmacological relevance of these venoms is discussed.

Estrés y desempeño laboral de los colaboradores de una red de salud / Stress and work performance of a health network staff

El estudio tuvo el objetivo de establecer la relación entre el estrés y el desempeño laboral de los colaboradores de la Red de Salud de Trujillo en 2019. Durante el proceso investigativo se siguió una metodología no experimental, a través de un estudio correlacional, de corte transversal, con un enfoque mixto; en el que participaron 98 colaboradores de ese entorno. Los investigadores realizaron el análisis empleando dos variables relacionadas con el ambiente laboral: estrés y desempeño. El 98% de los colaboradores mostró niveles medio y alto de estrés laboral y el 39,8% tuvo un desempeño laboral catalogado como regular. Se concluyó que el coeficiente de Rho de Spearman permitió establecer una correlación negativa y moderada entre estrés y desempeño laborales.

The study aimed to establish the relationship between stress and work performance of the staff of the Trujillo Health Network in 2019. During the research process, a non-experimental methodology was followed, through a correlational, cross-sectional study, with a mixed approach; in which 98 collaborators from that environment participated. The researchers carried out the analysis using two variables related to the work environment: stress and performance. Most of the collaborators (98%) showed medium and high levels of work stress and 39.8% had a work performance classified as regular. It was concluded that the Spearman's Rho coefficient allowed establishing a negative and moderate correlation between stress and work performance.

First symbols in a girl with Down syndrome: a longitudinal study from 12 to 18 months.

Symbolic uses of objects originate in communicative and triadic contexts (adult-child-object). In this longitudinal study we explore the emergence and development of the first symbolic uses in triadic interaction contexts in a girl with Down syndrome between 12 and 18-months of age. We conducted five sessions of video recording, at 12, 13½, 15, 16½, and 18 months chronological age. At each session we videotaped the girl and her mother interacting with different objects. Data were coded in semiotic categories used in previous studies (Rodríguez & Moro, 1999) and a microgenetic analysis was conducted for each session. The first symbolic uses by the girl appeared at 13½ months. Symbols were of different types and levels of complexity, and the adult had an important role in facilitating the production of these symbols.

Aislamiento y caracterización de micromicetos biodegradadores de polietileno

La biodegradación del polietileno por microorganismos es una solución para la reducción de la contaminación por plásticos. En el presente trabajo se muestran los resultados del aislamiento y caracterización de cepas de hongos capaces de degradar el polietileno, así como la determinación de las condiciones de pH y temperatura en las que se logran la mayor actividad. Los hongos fueron aislados de productos elaborados con polietileno obtenidos de relleno sanitario, la identificación taxonómica en base a características macroscópicas del crecimiento en placa petri y el estudio microscópico empleando la técnica de microcultivo en lámina. La actividad biodegradadora se determinó con la técnica de Kavelman y Kendrick, a temperaturas entre 20 y 30 °C y a pH 4,5 8,0. Veinte cepas de micromicetos fueron aisladas e identificadas, en 5 (25%) se evidencio la capacidad de biodegradar el polietileno a 20 °C, siendo el pH 6,5 el óptimo, la cepa de mayor rendimiento pertenece a la especie de Aspergillus flavus. A temperatura de 30 °C, 6 (30%) cepas evidenciaron actividad degradadora, siendo pH 6,5 el óptimo, la cepa de mayor rendimiento fue la misma del caso anterior.

The polyethylene biodegradation by microorganisms is a solution for the reduction of the plastics pollution. Isolation and characterization of the fungi capable to degrade the polyethylene are reported, as well as the conditions of pH and temperature in which they showed the higher activity. Fungi were isolated from polyethylene products obtained of sanitary landfill; the identification was realized in base to growth in petri plate and the technique of microculture in sheet. Biodegradative activity was determined with the Kavelman and Kendrick technique, for temperatures between 20 and 30 °C and to pH 4,5 8,0. Twenty strains of micromicete were isolated and identified. Five strain (25%) shown polyethylene biodegradative capacity to 20 °C, and pH 6,5. Six strain (30%) showed activity biodegradative to 30 °C, and pH 6,5. In both cases, Aspergillus flavus was the strain with greater performance.